One of the unique unexplored properties of Anadrol is that as a derivative of dihydrotestosterone it has very high estrogenic activity. As a rule, anabolic steroids – derivatives of DHT – are not endowed with the properties to be converted into estrogens by the enzyme aromatase and therefore do not exhibit estrogenic effects. In this sense, Anapolon is clearly different from the others. Anadrol is known to cause water retention in the body, gynecomastia and other side effects characteristic of estrogens without even converting to estrogen. Anadrol is believed to act like estrogen in certain tissues. This feature is described and discussed in detail below. But those looking at Anadrol should understand that the drug is a derivative of DHT but does not exhibit the effects and effectiveness inherent in dihydrotestosterone. Anadrol cannot convert to estrogens, since aromatase inhibitors cannot cope with the estrogenic manifestations characteristic of the drug.
Anadrol has high hepatotoxicity and side effects
As a potent C-17 alpha-alkylated oral anabolic steroid, Anadrol has high hepatotoxicity and side effects on the liver. In terms of toxicity, the drug is actually the most dangerous of all commercially available anabolic steroids. This characterization of the drug is common among bodybuilders and most likely exaggerated, but nevertheless such information should be taken very seriously. Interestingly, Anadrol has a chemical structure that is supposed to reduce hepatotoxicity. In fact, using Anapolon increases the level of liver enzymes. This has been shown in studies of patients diagnosed with HIV and AIDS. In order to avoid irreversible consequences, it is highly recommended to limit the intake of the drug for a period of 4-6 weeks and to use Anapolon in conjunction with a variety of proven liver support drugs.
When you look at the other side effects of Anadrol, things get even more confusing. It is well known that Anadrol is a derivative of dihydrotestosterone and does not convert to estrogen. However, Anadrol is characterized by side effects that occur when taking estrogens: water retention in the body (often manifested to an extreme degree) with a simultaneous increase in blood pressure and the development of gynecomastia. The use of selective estrogen receptor modulators (or Nolvadex) reduces the manifestations of gynecomastia, but does not solve the problem of edema and hypertension. Also, aromatase inhibitors will not work with Anadrol as it does not interact with this enzyme at all. Anadrol can presumably act like a progestogen and cause similar side effects. It is very likely (although not certain) that Anadrol can interact directly with the estrogen receptor, or perhaps the Anadrol metabolite has a similar property.
The evidence for abnormalities in Anadrol metabolites becomes even stronger when other side effects are examined. The manifestation of androgenic side effects is much less than, for example, testosterone. However, Anadrol is not converted to DHT, but is instead metabolized to 17-alpha-methyldihydrotestosterone (mestanolone). Mestanolone is the strongest androgen, so Anapolon use causes a number of androgenic side effects, such as: E.g.: oily skin, acne (very severe), baldness (both male and female), benign prostatic hyperplasia, etc.
Anadrol 50 on the body
I think in order to get a full picture of the effects of Anadrol 50 on the body, we need to look at its pros and cons. Anadrol is a DHT-derived compound and is a 17-alpha-alkylated steroid, meaning it has been altered at the 17-carbon position to survive when taken orally. Most oral steroids contain 17 amino acids and this helps them pass through the liver in a useful form. Sounds great right? Let’s 17alpha alkylate everything! As you can see, there is a downside as well.